04-10-2020

4.3
04-10-2020

little post about augmentin

Causes of respiratory infections

The causative agents of respiratory infections are divided into groups according to the etiological factor:

Respiratory tract infections

The source of infection is a sick person or carrier of an infectious agent. augmentin online The infectious period with respiratory tract infections most often begins with the onset of symptoms of the disease.

The mechanism of infection is aerogenic, including the airborne droplet (infection by contact with the patient by inhalation of aerosol particles during sneezing and coughing), air-dust (inhalation of dust particles with the infectious pathogens contained in it). With some infections of the respiratory system, due to the stability of the pathogen in the external environment, transmission factors are important - household items that fall on the patient's discharge when coughing and sneezing (furniture, scarves, towels, dishes, toys, hands and others). These factors are relevant in the transmission of infections for diphtheria, scarlet fever, mumps, tonsillitis, tuberculosis.

Respiratory infection infection mechanism

The susceptibility to respiratory tract infections is universal, people from early childhood to the elderly can become infected, but the peculiarity is the mass coverage of a group of children in the first years of life. No dependence on gender, equally sick, both men and women.

Side effects of the drug

If we compare the drug "Augmentin" with other antibiotics, then we can say that it is practically harmless. But still, he has side effects, and you can’t keep silent about them.

One of the most common of these is dysbiosis. Patients experience constipation, diarrhea, discomfort in the epigastrium, candidiasis on the mucous membranes, skin, and genitals. This is because any antibacterial agent is aimed at killing bacteria (both pathogenic and those that are part of the normal microflora of the body).

Adverse reactions affecting the nervous system are possible. They appear in the form of dizziness, anxiety, insomnia, headaches.

Adverse reactions also include allergic manifestations. The worst of them is anaphylactic shock. But more often itching, urticaria.

Taking the drug can provoke an attack of vomiting.

The color of tooth enamel may change when taking the suspension.

Pathological changes in the liver and kidneys in people suffering from chronic lesions of these organs, as well as in the elderly.

Seizures while taking the drug can occur in people with kidney failure..

The drug "Augmentin" is not able to cause drug dependence, and also does not affect the response rate, human coordination (can be used while driving).

An overdose is manifested by negative symptoms from the gastrointestinal tract. In this case, symptomatic therapy is performed. It is aimed at restoring the water-salt balance in the body, hemodialysis is possible.

pharmachologic effect

Farmgroup: semisynthetic antibiotic-penicillin + betalactamase inhibitor. Pharmacological action: Combined preparation of amoxicillin and clavulanic acid - a beta-lactamase inhibitor. It acts bactericidal, inhibits the synthesis of the bacterial wall. It is active against aerobic gram-positive bacteria (including strains producing beta-lactamases): Staphylococcus aureus; aerobic gram-negative bacteria: Enterobacter spp., Escherichia coli, Haemophilus influenzae, Klebsiella sppr. only in vitro sensitive: Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus anthracis, Streptococcus pneumoniae, Streptococcus viridans, Enterococcus faecalis, Corynebacterium spp., Listeria monocytogenes; anaerobic Clostridium spp., Peptococcus spp., Peptostreptococcus spp.; aerobic gram-negative bacteria (including beta-lactamase producing strains): Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp., Bordetella pertussiserial Yersella coli, Yeris cereissella, Yesseris vulgaris, Yesserium gibnica meningitidis, Neisseria gonorrhoeae, Haemophilus ducreyi, Yersinia multocida (formerly Pasteurella), Campylobacter jejuni; anaerobic gram-negative bacteria (including beta-lactamase producing strains): Bacteroides spp., including Bacteroides fragilis IV, clavulanic acid II, clavulans II and IV beta-lactamase, inactive against type I beta-lactamases, produced by Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid has a high affinity for penicillinases, due to which it forms a stable complex with the enzyme, which prevents the enzymatic degradation of amoxicillin under the influence of beta-lactamases. Pharmacokinetics: After oral administration, both components are rapidly absorbed in the digestive tract. Simultaneous ingestion does not affect absorption. TCmax - 45 minutes After oral administration at a dose of 250/125 mg every 8 hours, Cmax of amoxicillin - 2.18-4.5 μg / ml, clavulanic acid - 0.8-2.2 μg / ml, at a dose of 500/125 mg every 12 hours of Cmax amoxicillin - 5.09-7.91 μg / ml , clavulanic acid - 1.19-2.41 μg / ml, at a dose of 500/125 mg every 8 hours Cmax of amoxicillin - 4.94-9.46 μg / ml, clavulanic acid - 1.57-3.23 μg / ml, at a dose of 875/125 mg Cmax of amoxicillin - 8.82 -14.38 μg / ml, clavulanic acid - 1.21-3.19 μg / ml. After iv administration in doses of 1000/200 and 500/100 mg Cmax of amoxicillin - 105.4 and 32.2 μg / ml, respectively, and clavulanic acid - 28.5 and 10.5 μg / ml. The time to reach the maximum inhibitory concentration of 1 μg / ml for amoxicillin is similar when used after 12 hours and 8 hours in both adults and children. Communication with plasma proteins: amoxicillin - 17-20%, clavulanic acid - 22-30%. Metabolize both components in the liver: amoxicillin - by 10% of the administered dose, clavulanic acid - by 50%. T1 / 2 after taking a dose of 375 and 625 mg - 1 and 1.3 hours for amoxicillin, 1.2 and 0.8 hours for clavulanic acid, respectively . T1 / 2 after iv administration at a dose of 1200 and 600 mg - 0.9 and 1.07 h for amoxicillin, 0.9 and 1.12 h for clavulanic acid, respectively. It is excreted mainly by the kidneys (glomerular filtration and tubular secretion): 50-78 and 25-40% of the administered dose of amoxicillin and clavulanic acid are excreted, respectively, unchanged for the first 6 hours after administration.