Can Collagen Help with Pelvic Organ Prolapse

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Can Collagen Help with Pelvic Organ Prolapse

The pelvic floor is often-overlooked in preventive health, but one of the most thought-about parts for those suffering incontinence and organ prolapse.

Will Collagen Help Strengthen My Pelvic Floor?

The pelvic floor is an often-overlooked part of the body with regard to preventive health, but one of the most thought-about parts of the body for those suffering from common conditions such as incontinence and organ prolapse.

I speak from both personal and professional experience, having experienced stress urinary incontinence after the birth of my second child, a stage 2 uterine prolapse about 7 or 8 years after my first was born, and a stage 2 rectocele that slowly progressed, and I lived with for 9 years. Even though I knew a few things about prevention in childbirth, I had overlooked recovery and also developed chronic constipation (due to the hormone upheaval of perimenopause and an autoimmune response) I still developed pelvic floor dysfunction. I know the physical and emotional toll it can take. I also know that so many things are treatable and ‘figureoutable’ (to quote Marie Forleo) with the right information and regimen in place.

What Is The Pelvic Floor?

The pelvic floor is a group of muscles responsible for maintaining our continence, pelvic and spinal stability, sexual response and organ support. There are 3 layers of pelvic floor muscles in the pelvis, as well as ligaments, tendons and a huge vascular network. We need strong pelvic floor muscles, ligaments, and tendons, as well as good blood flow and circulation for optimal function. Many women birth babies, and every woman will go reach menopause which are 2 pivotal times in the life of our pelvic floor.

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It is also important to note that as we age, we lose muscle mass, hyaluronic acid and collagen, which can all directly influence the functioning of the pelvic floor muscles. It is also common for people with existing pelvic floor challenges to stop exercising, which can inhibit blood flow even more while also contributing further to decreases in muscle mass and strength. Strengthening the pelvic floor muscles is a key part of improving and maintaining function; however, can we possibly gain benefit from supplementing with collagen in addition to pelvic floor exercise?

This is a question I get asked all the time, and I wanted to look deeper into the research to see if it supported my belief and also to present what we currently know about collagen so others can make their own decision.

What Is Collagen?

Collagen is the most abundant protein in the body and provides structural support to what is known as the extracellular matrix of connective tissues. Collagen is what contributes to our skin’s firmness and resiliency and is often thought of as the ‘glue’ that holds everything together. While it is mainly thought of as a skin-supporting supplement, collagen is also found in muscles, bones, tendons, ligaments and blood vessels. As we age, we produce less and less collagen – about 1% less each year starting around the age of 20. This can lead to less buoyancy and resiliency in our tissues as well as drier, thinner skin.

How Does Collagen Relate To The Pelvic Floor?

There are many different types of collagen, with the most common types being Type I through IV. Type I collagen comprises over 90% of the collagen in the human body, and with regards to the pelvic floor, we find Types I and III. Collagen is one of the most important parts of the extracellular matrix and plays a support role in the pelvic floor. A study by Norton et al showed that women with joint hypermobility have a significantly higher prevalence of pelvic organ prolapse, from which we can infer that connective tissue integrity plays a role. Fibrous connective tissue and the pelvic floor muscles support the vaginal walls, with collagen types I and III playing a significant role in tissue tensile strength. One study found conclusively that women younger than 53 years of age with pelvic organ prolapse have 30% lower collagen concentration compared to age-matched controls, which indicates a constitutional tissue weakness contributing to prolapse development.

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Another study wanted to see if there was a correlation between the clinical stage of pelvic organ prolapse (POP), histological structure and results of immunohistochemical study of the vaginal wall. There were 60 postmenopausal women who had undergone some type of pelvic surgery during which a biopsy of the vaginal tissue was taken. There were 3 groups in this study - group 1 was women with a stage I or II prolapse, while the 2nd group was women with a stage III or IIII prolapse. The third group was women with no prolapse. They found a significant difference in the connective tissue of group 2, namely the degradation of collagen fibers with a decrease in connective tissue strength and elasticity. They found that women with POP had a low ratio of type I:III collagen. Analysis of the collagen content in the vaginal wall in patients with mild POP (I-II) revealed a significant increase in the level of collagen type I and a decrease in the content of type III, compared to patients with more severe POP (III-IV).

We also have evidence to show that pelvic organ prolapse and other collagen-associated disorders may have a common etiology originating at the molecular level of the collagens. A gynecologist and a molecular biologist completed a rodent study and were able to demonstrate that prolapse is caused by a combination of loss of elasticity and breakdown of proteins in the vaginal walls. Chen et al looked at collagen metabolism and turnover in women with stress urinary incontinence and found increased collagen breakdown as a pathologic etiology of incontinence.

A similar study found a reduced expression of types I and III collagen in the anterior vaginal wall tissues, which may play an important role in the onset of POP.

To further understand what we know about collagen and the types in the pelvic floor as well as possible links to POP and other disorders, I highly recommend giving this article a read.

Does Collagen Supplementation Help?

There is no evidence specific to collagen supplementation and the pelvic floor…yet. Until we have research, we can look at how collagen supplementation helps with other factors in the body, such as skin, muscles, bones, hair, and nails. This study used a specific collagen that is more easily absorbed - bioactive collagen peptide (BCP) - called Verisol®. In the study, they wanted to determine the effectiveness of the BCP on eye wrinkle formation and stimulation of procollagen 1, elastin and fibrillin biosynthesis. Elastin, like collagen, is also a key extracellular matrix protein. Fibrillin is a glycoprotein that gets secreted into the extracellular matrix by fibroblasts and is thought to provide a ‘scaffolding’ for the deposition of elastin. They found that ingestion of the specific BCP promoted a statistically significant reduction of eye wrinkle volume compared to the placebo group after 4 and 8 weeks (20%) of intake.

Moreover, a positive, long-lasting effect was observed 4 weeks after the last BCP administration. Additionally, after 8 weeks of intake, a statistically significantly higher content of procollagen type I (65%) and elastin (18%) in the BCP-treated volunteers, compared to the placebo-treated patients, was detected. For fibrillin, a 6% increase could be determined after BCP treatment compared to the placebo, but it was not statistically significant. Their findings demonstrate that oral intake of the specific bioactive collagen peptides (Verisol®) reduced skin wrinkles and had positive effects on dermal matrix synthesis. Knowing that the pelvic floor has type I collagen, we can speculate that oral intake of this specific BCP may also influence those tissues.

Will Collagen Cure My Prolapse or Incontinence?

We have no data on the use of collagen as it pertains to the pelvic floor. While I know people with early-grade prolapse or urinary incontinence who have seen or felt improvements in their symptoms, collagen will not cure the conditions outright. The specific bioactive collagen compound used in the above study shows wonderful results for the skin, and knowing that we lose collagen as we age and that it was mainly type I collagen, which we have in the pelvic floor, supplementing with collagen seems like a good option for some who are wishing to support their bones, skin, muscles, ligaments, tendons, blood vessels and pelvic floor.

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Supplementing with the bioactive collagen peptides and other known beneficial therapies, namely exercise, must be considered. Combining resistance training with collagen peptides can help with bones, muscles and even strength, as found in this study. The study's objective was to assess the influence of post-exercise protein supplementation with collagen peptides v. placebo on muscle mass and muscle function following resistance training in elderly subjects with sarcopenia. 53 subjects (all male) underwent a 12-week guided resistance training programme (three sessions per week). They were supplemented with either collagen peptides (treatment group (TG)) (15 g/d) or silica as a placebo (placebo group (PG)).

Following the training programme, all the subjects showed significantly higher levels for fat-free mass, bone mass, isokinetic quad strength and sensory-motor control with significantly lower levels for fat mass. The effect was significantly more pronounced in subjects receiving collagen peptides. We can again speculate that there may be a benefit to oral supplementation of a specific bioactive collagen peptide and perhaps see even further benefit if it is combined with the whole body and pelvic floor muscle-specific exercise. A similar study looked at 77 premenopausal women and found that resistance training in combination with supplementation of specific collagen peptides induced a significantly higher increase in fat-free mass and hand-grip strength than resistance training and placebo supplementation.

In addition, there was a significantly higher loss in fat mass and a more pronounced increase in leg strength in the treatment group compared to the control group. We know from this systematic review, that collagen peptide supplementation is most beneficial in improving joint functionality and reducing joint pain. We also know from this study that the intake of specific collagen peptides increased bone mineral density in postmenopausal women with a primary, age-related reduction of bone mineral density. In addition, specific collagen peptide supplementation was associated with a favourable shift in bone markers, indicating increased bone formation and reduced bone degradation.

Knowing this information and also that as we age, we lose muscle mass and that the menopause transition increases our risks of osteoporosis, joint pain, weight gain and incontinence, perhaps supplementing with collagen would be worth considering as a possible way to slow down or minimize the increased risks we face around midlife? I know that I am not waiting for research about collagen and the pelvic floor. I am supplementing now.

What Else Helps Collagen Production?

This was an interesting article that evaluated the effect of vitamin D in preventing pelvic organ prolapse by aggregating elastin and collagen expression. They looked at cell cultures from the utero-sacral ligament from female patients undergoing hysterectomy. They divided the cells into various groups that would be exposed to different levels of vitamin d and one group that was not exposed to vitamin d at all. They found that vitamin d exposure had a significantly positive effect of increasing extracellular matrix expression with the most effective dose of vitamin d for collagen expression being 800 μM. It is also interesting to note that there is a correlation of low vitamin d with pelvic floor disorders. This study looked at postmenopausal women in particular while this study looked at a broader age range and found that mean vitamin D levels were significantly lower for women reporting at least one pelvic floor disorder and for those with urinary incontinence, irrespective of age. The researchers observed significantly decreased risks of one or more pelvic floor disorders with increasing vitamin D levels in all women aged 20 or older and in the subset of women 50 years and older. Additionally, the likelihood of urinary incontinence was significantly reduced in women 50 and older with vitamin D levels 30 ng/mL or higher.

Which Collagen Supplement Is Best?

There are so many collagen supplements on the market which can make it hard to know which form is best. I have tried a lot and never really noticed much and was always researching new ones because I wanted the best. Then I heard about Verisol® and the associated research (some listed above) and set out to find a product with it because it makes sense to use the one backed by research. The one I found and now use is Beauty Focus Collagen+ by NuSkin. I also love that it contains Lutein which is a carotenoid that protects our skin from oxidative stressors but is also important for eye health.

I have a family history of eye concerns, so eye health is very important to me. This collagen also has phytoceramides, which are fat lipids in our skin cells that form a barrier that keeps moisture in and protects our skin from damage. My goals are to have glowy, supple skin with few deep wrinkles, healthy eyes, strong bones, resiliency in my pelvic floor and strong muscles. This collagen ticks all the boxes for me and is part of my daily healthcare routine.

For those interested in trying the collagen I use, there are different links depending on whether you are in Canada or the USA or the UK

For people living in Canada Canadians click here

For people living in the USA Americans click here

For people living in the UK UK folk click here

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I also like this one from Totally Derma - great list of ingredients! Totally Derma® is scientifically proven to increase collagen, elastin and hyaluronic acid in the body and skin. It has been specifically formulated to reduce inflammation, and support and improve skin health, joint health, gut health, and menopausal health.

It is important to note that the unique Totally Derma® formulation contains therapeutic doses of 10,000 mg. patented *Arthred® collagen amino acid peptides, patented Synovoderma® hyaluronic acid and high levels of 5 key antioxidants, anti-inflammatories and 2 minerals for optimum collagen production, maintenance, and repair.

Totally Derma - US and Canadian customers:

use code VAGINCOACH10 to save 10% off a 30 day supply and VAGINACOACH15 to save 15% off a 90 day supply

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TotallyDerma 90 day supply

Totally Derma - UK customers:

use code VAGINCOACH10 to save 10% off a 30 day supply and VAGINACOACH15 to save 15% off a 90 day supply.

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References

Female Pelvic Floor Anatomy: The Pelvic Floor, Supporting Structures, and Pelvic Organs

Genitourinary prolapse and joint hypermobility in women

Pelvic organ prolapse and collagen-associated disorders

Protein breakdown contributes to pelvic organ prolapse

Collagen metabolism and turnover in women with stress urinary incontinence and pelvic prolapse

Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis

Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomized controlled trial

Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial

The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review

Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study

Effect of Vitamin D on Elastin and Collagen Expression: In Vitro Study of Pelvic Organ Prolapse Prevention

Vitamin D deficiency in postmenopausal women with pelvic floor disorders

Vitamin D and pelvic floor disorders in women: results from the National Health and Nutrition Examination Survey

Morphologic structure and immunohistochemical analysis of vaginal wall in women with pelvic organ prolapse

Expression and Significance of Metalloproteinase and Collagen in Vaginal Wall Tissues of Patients with Pelvic Organ Prolapse

Changes in connective tissue in patients with pelvic organ prolapse—a review of the current literature