Oxytocin—An Opioid-Free Choice For Musculoskeletal Pain

Oxytocin—An Opioid-Free Choice For Musculoskeletal Pain

The common characteristics of musculoskeletal pain can differ in everyone depending on which part of the body is in pain.

Pain is the most common reason why people visit a physician for care. It can be detrimental to a person's quality of life and is extremely difficult to treat. People experiencing disturbing pain management will try almost everything from opioid pain relievers with intriguing side effects to alternative medicine to find relief when their body is making them uncomfortable.

According to the research published by the Centers for Disease Control and Prevention in 2018, about 50 million people in the U.S. live with some type of chronic pain. Chronic pain could be considered one of the biggest health problems plaguing the country. Usually, one out of every five people is physically hurting regularly. While chronic discomfort can stem from many underlying problems, musculoskeletal pain is commonly blamed.

Pain is the result of more than one cause. Pain can have major psychological factors. Not every person suffering from the same type of pain will experience the same intensity of pain. Those dealing with chronic pain constantly try numerous approaches to relieve their symptoms, whether physical therapy, meditation, prescription medications, or others.

Pain may also be extremely difficult to treat because prescription medications tend to be effective and safe at a particular dosage for a particular amount of time. Using opioids in the long term can develop a tolerance against the medication in the person using it. It might result in the need for higher dosages and put the person at high risk for addiction.

What Is Musculoskeletal Pain?

Musculoskeletal pain is a type of pain that affects ligaments, joints, muscles, bones, or tendons in the body. There are several causes of this form of pain, such as below:

Injury in any part of the musculoskeletal system

Certain conditions or diseases, for example, arthritis or fibromyalgia

Overuse or overexertion of some parts of the musculoskeletal system

Prevalent Characteristics of Musculoskeletal Pain

The common characteristics of musculoskeletal pain can differ in everyone depending on which part of the body is in pain. For instance, someone experiencing bone pain may feel a deep, sharp, and stabbing sensation that is more unresting than something like muscle pain. Similarly, joint pain tends to cause stiffness or aching. Some common signs that can come along with musculoskeletal pain include:

Overall soreness


Stiffness or mobility interference

Muscle spasms

Weakness or adrenal fatigue symptoms

While not all types of musculoskeletal pain will prevail forever, many people experience prolonged discomfort, which is called chronic pain. For reference, pain that remains for more than three to six months is considered chronic. Although the most common type of musculoskeletal pain is lower back pain, people can also suffer from tendon pain, ligament pain, joint pain, muscle pain, or other discomforts.

Treating Musculoskeletal Pain

Let's look at musculoskeletal pain, how oxytocin nasal spray may help, and typical treatment methods.

Using Oxytocin As A Treatment for Musculoskeletal Pain

Oxytocin is a hormone produced by the body which plays many significant roles in the body. For many years, medications based on oxytocin have been known mainly for helping uterine contractions during delivery. As one of the natural hormones produced in the brain and then secreted by the pituitary gland, oxytocin is believed to play a role in everything from emotions to sexual functions and bonding.

Recently, evidence has suggested that oxytocin may help decrease sensitivity to pain. Research also proves that oxytocin improves mood despite the discomfort. It may even help those dealing with chronic levels of pain. The best thing of all, oxytocin is opioid-free and may be beneficial for people living with a list of discomforting pains.

The neuropeptide in oxytocin has been proven to help lower pain levels associated with:

  • Colon pain
  • Constipation
  • Chronic lower back pain
  • Nerve pain
  • Pelvic pain
  • Postoperative pain

Multiple things make oxytocin a viable candidate for helping people who deal with chronic pain. First, oxytocin stimulates the release of natural opioids in the brain. Second, oxytocin helps improve mood and potentially lower stress response, which are both an issue among most people dealing with severe pain. Third, oxytocin activates GABA neurons that can stop pain response.

Use of Oxytocin for Pain

As observed, some studies on oxytocin and various types of pain examine it as intravenous or subcutaneous medication. Some of the research claims that oxytocin nasal spray seems to offer similar results.

Pelvic Pain

Several factors can cause pelvic pain. It is usually hard to treat it because of due to this. A study of 21 women with chronic pelvic pain showed that oxytocin nasal spray offers relief for at least one in three participants. The group of women in the study was given either a placebo or oxytocin nasal spray to use for 14 days. The improvement in the pain sensations was significant, but they reported no adverse effects.

Nerve Pain

Nerve pain, also known as neuropathic pain, is one of the most difficult types of pain to treat. Although musculoskeletal pain and neuropathic pain are two different things, these may be closely related to each other in the human body. The studies carried out on animals in 2018 show that oxytocin lowers sensitivity to many types of pain related to neuropathic pathways.

Chronic Lower Back Pain

A study of 22 male patients with chronic low back pain proved that Oxytocin intranasal spray lowers intensity levels of pain. While further studies are required on the pain-relieving effects for chronic back pain sufferers, this study does show effectiveness. Oxytocin nasal spray could be a good conjunctive form of therapy that sufferers could use to reduce their reliance on opioids or other treatments.

Postoperative Pain

According to evidence, oxytocin may help lower the levels of postoperative pain. Thirty patients were given subcutaneous (under the skin) oxytocin, lidocaine, or a placebo before laparoscopic surgery in a study published in the European Journal of Pain in 2019. Patients given lidocaine and oxytocin experienced less postoperative pain.

Find Oxytocin Nasal Spray at Habror

With oxytocin having a relatively good safety profile and several effective offerings, oxytocin nasal spray is a potential way to deal with pain. You may be interested in trying. The oxytocin nasal spray is available in the compounding pharmacies like Harbor Compounding Pharmacy. If you are a sufferer of chronic pain or continual musculoskeletal discomfort, please contact us so we can discuss all the available options better than opioid medications. Our compassionate pharmacists will work with you and your doctor to find the best medicinal solutions.

Alternative Options For Treating Musculoskeletal Pain

Other options a doctor may do or recommend to help a patient with physical discomfort include:

  • Therapeutic massage
  • Steroid injections
  • Physical therapy
  • Chiropractic musculoskeletal adjustments
  • Splints or braces


Moreover, people who are consistently uncomfortable physically can have problems with stress and mood. Therefore, it is not uncommon for chronic pain patients to be prescribed something like antidepressants or anxiety medications.